Aiming at the problem that TelemeTry and Command (TT&C) Message-Oriented Middleware (MOM) with traditional model like message queue and shared memory has the disadvantage of tightly coupling and limited extensible ability. Combining with the current characteristics of TT&C computer system, a function distributed TT&C MOM system with Publish/Subscribe (Pub/Sub) model was put forward. Centralized publish/subscribe server was canceled with its function embedded into the distributed processing unit. The working process of themes global registration, subscriptions global broadcasting and event local matching were designed. And its transmission reliability was achieved through the reliable multicast protocol, its nodes reliability was achieved by soft duplex with virtual IP mechanism and accelerated push-pull heartbeat detection. Experiments show that the average response time of Pub/Sub message is controlled within 100 ms, the packet loss rate of multicast protocol is around 0.86×10^-7, duplex switch delay is up to 56 ms. This TT&C MOM system with Pub/Sub model satisfies the requirement of highly real-time performance and reliability of TT&C applications.